Target Screening - Medigene AG

The choice of the right epitope to be recognized by TCRs is critical for reducing off-target toxicities. Bioinformatic tools like our proprietary EXPITope-M tools enable the examination of the expression of newly identified epitopes in healthy tissue, especially in vital organs like the heart and brain, to avoid unspecific binding of TCRs leading to fatal damage to healthy tissue.

Target Screening Publications

Machine Learning for Cancer Immunotherapies Based on Epitope Recognition by T Cell Receptors

Anja Mösch, Silke Raffegerst, Manon Weis, Dolores J. Schendel and Dmitrij Frishman. Frontiers in Genetics Review published: 19 November 2019 doi: 10.3389/fgene.2019.01141

Assessment of cancer and virus antigens for cross-reactivity in human tissues

Jaravine, V., Raffegerst, S., Schendel, DJ., Frishman, D. Bioinformatics 2017 Jan 1;33(1):104-111. doi: 10.1093/bioinformatics/btw567.

Expitope: a web server for epitope expression

Haase, K., Raffegerst, S., Schendel, D., Frishman, D. Bioinformatics. 2015 Jun 1;31(11):1854-6. doi: 10.1093/bioinformatics/btv068.

Adoptive tumor therapy with T lymphocytes enriched through an IFN-γ capture assay

Becker, C., Pohla, H., Frankenberger, B., Schüler, T., Assenmacher, M., Schendel, D.J. and Blankenstein, T. 2001. Nat Med.; 7 (10):1159–1162.

Target Screening Abstracts

CAR-TCR Summit

Combined Molecular & Cellular Tools are Required to Assess Safety of TCR-T Immunotherapies; Tristan Holland

Presentation

CIMT – Cancer Immunotherapy Annual Meeting 2013, Mainz

Wehner C., Ellinger C., Raffegerst S., Wilde S., Mosetter B., Schendel D.J., Milošević S., 2013. Isolation of antigen-specific CD8+ T lymphocytes and molecular characterization of antigenic epitopes. CIMT Mainz, Germany.

Download PDF